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This risk of bleeding should be weighed against the urgency of intervention.

​ If surgery cannot be delayed, there is an increased risk of bleeding. Pediatric patients with an eGFR <50 mL/min/1.73m 2 have not been studied, avoid use of PRADAXA Capsules in these patients. If possible, discontinue PRADAXA Capsules in adults 1 to 2 days (CrCl ≥50 mL/min) or 3 to 5 days (CrCl 80 mL/min/1.73m 2) or 2 days before an elective surgery (eGFR 50-80 mL/min/1.73m 2). One 110 mg capsule plus two 75 mg capsules twice dailyĭiscontinuation for Surgery and Other Interventions

One 150 mg capsule plus one 110 mg capsule twice daily One 110 mg capsule plus one 75 mg capsule twice daily Table 1 Weight-Based PRADAXA Capsules Dosing for Pediatric Patients Aged 8 to Less Than 18 Years ​ Actual Weight (kg) Adjust the dose according to actual weight as treatment progresses. ​ The recommended dose of PRADAXA Capsules for the treatment of or reducing the risk of VTE in pediatric patients 8 to less than 18 years of age is based on the patient's actual weight as shown in Table 1 below. The dosing interval should be as close to 12 hours as possible. ​ PRADAXA Capsules is dosed orally twice daily, one dose in the morning and one dose in the evening, at approximately the same time every day. For reduction in risk of recurrence of VTE, initiate treatment following previous treatment. For the treatment of VTE in pediatric patients, initiate treatment following treatment with a parenteral anticoagulant for at least 5 days. Other age-appropriate pediatric dosage forms of dabigatran etexilate are available for pediatric patients less than 8 years of age. ​ PRADAXA Capsules can be used in pediatric patients aged 8 to less than 18 years of age who are able to swallow the capsules whole. Recommended PRADAXA Capsules Dose for Pediatrics Reduction in the Risk of Recurrence of DVT and PEĭosing recommendations cannot be providedġ10 mg for first day, then 220 mg once dailyĬrCl <50 mL/min with concomitant use of P-gp inhibitors:

Reduction in Risk of Stroke and Systemic Embolism in Non-valvular AF Recommended PRADAXA Capsules Dose for Adults Indication